Positive psychology is a relatively new field of study that aims to understand and promote human well-being and happiness. It studies what makes people happy, resilient, and fulfilled.

Unlike traditional psychology, which focuses primarily on treating mental illness and negative emotions, positive psychology focuses on the positive aspects of human experience, such as positive emotions, strengths, and virtues. It also explores positive experiences, such as joy, gratitude, and love, as well as positive traits, such as creativity, courage, and wisdom.

The origins of positive psychology can be traced back to the late 1990s, when Martin Seligman, a renowned psychologist and researcher, began to shift his focus from traditional clinical psychology to the study of positive human experience. Seligman’s work laid the foundation for the field of positive psychology, which has since grown to include a wide range of research and applications.

One of the key tenets of positive psychology is the belief that human beings have the capacity for growth and development throughout their lives. This is in contrast to traditional psychological models, which often view people as being stuck in a particular stage or pattern of behavior. Positive psychology encourages individuals to focus on their strengths and to strive for self-improvement and personal growth.

Another important aspect of positive psychology is the emphasis on positive emotions and experiences. Positive emotions such as joy, contentment, and gratitude are seen as essential for well-being and happiness. Positive psychology also encourages individuals to seek out new experiences and to engage in activities that bring them pleasure and satisfaction.

In addition to its focus on positive emotions and personal growth, positive psychology also emphasizes the importance of social connections and relationships. Strong social connections and supportive relationships are seen as key to well-being and happiness. Positive psychology encourages individuals to build and maintain strong relationships with family and friends, and to engage in activities that promote social connections.

The PERMA Model of Positive Psychology was developed by Dr. Martin Seligman, and was widely published in his 2011 book, “Flourish.”

“PERMA” Model identifies five essential elements to well-being. These are: Positive Emotions (P). Engagement (E). Positive Relationships (R). Meaning (M). Achievement/Accomplishment (A)

“Flourish: A Visionary New Understanding of Happiness and Well-Being” by Martin E. P. Seligman. Published by Free Press, 2011.

Overall, positive psychology is a rapidly growing field that offers a new perspective on human well-being and happiness. By focusing on positive emotions, strengths, virtues, and social connections, positive psychology encourages individuals to strive for personal growth and to live a fulfilling and meaningful life.

Various ways of utilizing the PERMA tools are: Doing hobbies and creative activities that you enjoy, Practicing living in the moment, even during daily activities or mundane tasks, Spending time in nature, watching, listening, and observing what happens around you, getting in touch with people you have not spoken to or connected with in a while, getting involved in a cause or organization that matters to you, creating SMART (specific, measurable, achievable, realistic, and time bound ) goals, celebrating achievements and Reflecting on past successes.

Training in PERMA can be helpful for improving performance, building resilience, and increasing success and life satisfaction. Here are three options for obtaining training in PERMA.

The Penn Resilience Program and PERMA workshops

The SAHMRI Wellbeing and Resilience Centre

The Science of Happiness Course

Action for Happiness offers an interactive library of 10 keys that leads to happier living, including Giving, Relating, Exercising, Awareness, Trying out, Direction, Resilience, Emotions, Acceptance, and Meaning: GREAT-DREAM)

Mihaly Csikszentmihalyi, one of the co-founders of positive psychology, was the first to identify and research flow. Flow is one of life’s highly enjoyable states of being, wrapping us entirely in the present, when we might be completely and utterly immersed in a task, oblivious to the outside world and highly focused on the present. Activities which we love doing, like playing music, dancing, gardening, singing, reading, being in nature, or a certain sport or exercise might create a flow state for us.

Flow states help us be more creative, productive, and happy.  The experience of flow is universal and has been reported to occur across all classes, genders, ages, and cultures, and it can be experienced during many types of activities. In 2004, Csikszentmihalyi delivered a TED Talk titled “Flow, the Secret to Happiness,” which has more than 6.7 million views.

 

Please share in comments what has contributed to your sense of happiness and wellbeing?

Have you ever experienced a flow state? What activity were your immersed in?

Which activities do you pursue to continue feeling happy?

How do you feel after doing them?

How long does that happiness last?

Any other benefit you might have noticed with those experiences?

 

 

This is an effort to make some of these resources easily available for you in one place.

Please feel free to reach out and let us know if there is another resource that you love, and we would add it to the list.

Enjoy!

AYURVEDIC HERBS, SPICES, OILS, AND FOOD SUPPLIES

Ayush Herbs, Inc.
10025 N.E. 4th Street
Bellevue, WA 98004
Ph. (800)925-1371
www.ayushherbs.com

Banyan Botanicals
6705 Eagle Rock Ave. NE
Albuquerque, NM 87113
Ph. (505) 821-5083; (888) 829-5722
www.banyanbotanicals.com

Bazaar of India Imports, Inc.
1810 University Avenue
Berkeley, CA 94703
Ph. (800) 261-7662; (510) 548-4110
www.bazaarofindia.com

Frontier Natural Products Co-op
P.O. Box 229
Norway, IA 52318
Ph. (800) 717-4372
www.frontiercoop.com

Internatural
33719 116th St./ Box AH
Twin Lakes, WI 53181 USA
Ph. (262) 889-858; (800) 643-422
Fax: (262) 889-8591
www.internatural.com

Maharishi Ayurveda Products
1068 Elkton Dr.
Colorado Springs, CO 80907
Ph. (800) 255-8332
www.mapi.com

Om Organics
3245 Prairie Avenue Suite A
Boulder, CO 80301
Ph. (888) 550-VEDA
Fax: (720) 406-9340
www.omorganics.com

Planetary Formulations
P.O. Box 533
Soquel, CA 95073
Formulas by Dr. Michael Tierra

Tri Health Ayurveda
P.O. Box 340
Anahola, HI 96703
Ph. (808) 822-4288; 800-455-0770
Fax: (808) 822-3856
www.oilbath.com

Here is a compilation of a few Yoga and Meditation Centers primarily based in the USA

(Note: See websites for worldwide locations)

This is an effort to make some of these resources easily available for you in one place.

Please feel free to reach out and let us know if there is another resource that you love, and we would add it to the list.

Enjoy!

MEDITATION CENTERS/ORGANIZATIONS

International Sivananda Yoga Vedanta Centers
The Art of Living Retreat Center
639 Whispering Hills Rd.
Boone, NC 28607
Phone: 800-392-6870
https://www.artofliving.org/us-en

International Sivananda Yoga Vedanta Centers
1746 Abbot Kinney Blvd.
Venice, CA 90291
Ph. (310) 822-9642
www.sivananda.org

ISHA Yoga Centers
951 Isha Lane,
McMinnville, TN – 37110,
Ph. (931) 668-1900
https://isha.sadhguru.org/us-en/isha-usa/

Self-Realization Fellowship
3880 San Rafael Ave. Dept. 8W
Los Angeles, CA 90065
Ph. (323) 255-2471
Fax: (323) 255-5088
www.yogananda-srf.org

Shambala International
1084 Tower Road
Halifax, NS Canada
Ph. (902) 425-4275
www.shambhala.org

Siddha Yoga Foundation
(SYDA Foundation)
P.O. Box 600
371 Brickman Rd.
South Fallsburg, NY 12747
Ph. (845) 434-2000
www.siddhayoga.org

The Transcendental Meditation Program (TM)
639 Whispering Hills Road, Suite 704
Boone, NC 28607
Ph. (888) 532-7678
www.tm.org

Vipassana Meditation Center
P.O.Box 24
Shelburne Falls, MA 01370
Ph. (413) 625- 2160
Fax: (413) 625-2170
www.dhamma.org


YOGA CENTERS/ORGANIZATIONS

American Viniyoga Institute
P.O Box 88
Makawao, HI 96768
Ph. (808) 672-1414
www.viniyoga.com

Kripalu Center for Yoga and Health
Box 793
Lenox, MA 01240
Ph. (800) 741-7353
www.kripalu.org

Iyengar Yoga Institute
27. W. 24th St. #800
New York, NY 10010
Ph. (212) 691-9642

Omega Institute for Holistic Studies
150 lake Drive
Rhinebeck, BY 12572
Ph. (845) 266-4444
www.eomega.com

Siddha Yoga Foundation
(SYDA Foundation)
P.O. Box 600
371 Brickman Rd.
South Fallsburg, NY 12747
Ph. (845) 434-2000
www.siddhayoga.org

Sivananda Yoga Vedanta Center
234 W. 24th St.
New York, NY 10011
www.sivananda.org

Yoga Studio Directory by State:
www.self-realization.com/yogadirectory.htm


VEDIC ASTROLOGY

American Council of Vedic Astrology
(ACVA)
P.O. Box 2149
Sedona, AZ 86339
Ph. (800) 900-6595
Fax: (520) 282-6097
www.vedicastrology.org

American Institute of Vedic Studies
P.O. Box 8357
Santa Fe, NM 87504-8357
Ph. (505) 983-9385
Fax: (505 )982-5807
www.vedanet.com
Correspondence courses in Ayurveda and Vedic Astrology

Dr. Suhas Kshirsagar
2541 Soquel Ave,
Santa Cruz, California 95062
Ph. (831) 462-3776
https://www.ayurvedichealing.net/

 

This is an effort to make some of these resources easily available for you in one place, including Ayurvedic Practitioners, Schools, Herbs, Supplies, and More

Please feel free to reach out and let us know if there is another resource that you love, and we would add it to the list.

Enjoy!

AYURVEDIC HEALTH CENTERS

Ayurveda Institute of America
Dr. Jay Apte BAMS
561 Pilgrim Dr. Suite-B
Foster City, CA 94404
www.ayurvedainstitute.com

The Ayurvedic Institute and Wellness Center
Dr. Vasant Lad MASc.
11311 Menaul, NE
Albuquerque, NM 87112
Ph. (505) 291-9698
Fax: (505) 294-7572
www.ayurveda.com

Ayurvedic and Naturopathic Clinic
Dr. Virender Sodhi, MD (Ayurved), ND.
2115 112th Ave. NE
Bellevue, WA 98004
Ph. (425) 453- 8022
Fax: (425) 451- 2670
www.ayurvedicscience.com

California College of Ayurveda
Dr. Marc Halpern D.C.
1117A East Main Street
Grass Valley, CA 95945
Ph. (530) 274-9100
www.ayurvedacollege.com

The Chopra Center for Well Being
Dr. David Simon M.D.
2013 Costa del Mar Rd.
Carlsbad, CA 92009
Ph. (760) 494-1608
Fax: (760)494-1608
www.chopra.com

Vedika Global
Dr. Pratichi Mathur

5950 Doyle St.
Emeryville, CA 94608

www.vedikaglobal.org

Kauai Center for Holistic Medicine and Research
Dr. Thomas Yarema MD
Dr. Suhas Kshirsagar MD (Ayurved)
Kapa’a HI, 96746
Ph. (808) 823-0994
Fax: (808)-823-0995
www.hawaiiholisticmedicine.com

Light Institute of Ayurveda
Dr. Bryan Miller D.C. & Light Miller ND., DD.
P.O. Box 35284
Sarasota, FL 34242
Ph. (941) 929-0999
Fax: (941)346-0800
www.ayurvedichealers.com

Maharishi Ayurved at the Raj
Dr. Nancy Lonsdorf M.D.
1734 Jasmine Avenue
Fairfield, IA 52556
Ph. (800) 248-9050
Fax: (515) 472-2496
www.theraj.com

National Institute Of Ayurvedic Medicine
Dr. Scott Gerson, M.D., Ph.D. (Ayurveda)
13 W. 9th St.
New York, NY 10011
Ph. (212) 505-8971
Fax: (212) 677-5397
www.niam.com

Natural Medcine Clinic
Dr. Vivek Shanbhag ND, MD (Ayurved), BAMS
819 NE 65th St.
Seattle, WA 98115
Ph. (206) 729-9999
www.ayurvedaonline.com

Pacific Center of Ayurveda
Prashanti de Jager
P.O Box 878
Marshall, CA 94940
Ph. (415) 246-1248
www.dhanvantri.com


AYURVEDIC EDUCATION/ CLINICAL TRAINING

Ayurvedic Mountain Retreat

Wellness studio at Breathe Yoga
14107-H Winchester Boulevard
Los Gatos, CA 95032 ( Fridays & Saturdays 9am-3pm)

www.ayurvedicmountainretreat.com

The Ayurvedic Institute
11311 Menaul, NE
Albuquerque, NM 87112
Ph. (505) 291-9698
Fax: (505) 294-7572
www.ayurveda.com

Australian College of Ayurvedic Medicine
PO Box 322
Ingle Farm SA 5098
Australia

Ayurvedic Academy & Natural Medicine Clinic
819 NE 65th Street
Seattle, Washington USA 98115
Phone: (206) 729 – 9999
FAX: (206) 729 – 0164
www.ayurvedaonline.com

The American School of Ayurveda
460 Ridgedale Avenue
East Hanover, New Jersey 07936
Ph. (973) 887-8828
Fax: (973) 887-3088
www.lotusfair.com

California College of Ayurveda
Dr. Marc Halpern D.C.
1117A East Main Street
Grass Valley, CA 95945
Ph. (530) 274-9100
www.ayurvedacollege.com

Diamond Way Ayurveda
P.O. Box 13753
San Luis Obispo, CA 93406
Ph. (805)543-9291
Toll-Free: (877)964-1395
www.diamondwayayurveda.com

East-West College of Herbalism
Ayurvedic Program
Hartswood, Marsh Green, Hartsfield
E. Sussex TN7 4ET
United Kingdom
Ph. 01342-822312
Fax: 01342-826346

European Institute of Vedic Studies
Atreya Smith, Director
Ceven Point N* 230
4 bis rue Taisson
30100 Ales, France
Fax: 33-466-60-53-72
www.atreya.com

Ganesha Institute
152 Caymus Court
Sunnyvale, CA 94086
www.healingmission.com

Himalayan Institute
RR1, Box 400
Honesdale, PA 18431
Ph. (800) 822-4547
www.ayurvedichealing.com

Institute for Wholistic Education
33719 116th Street/ Box AH
Twin Lakes, WI 53181
Ph. (262) 877-9396

International Academy of Ayurveda
Nand Nandan, Atreya Rugnalaya
Erandawana, Pune
411004, India
Ph./Fax: 91-212-378532/524427
www.ayurved-int.com

John Douillard
Life Spa, Rejuvenation through Ayurveda
3065 Center Green Drive
Boulder, CO 80301
Ph. (303) 442-1164
Fax: (303) 442-1240

Light Institute of Ayurveda
P.O. Box 35284
Sarasota, FL 34242
Ph. (941) 929-0999
www.ayurvedichealers.com

Maharishi Ayurveda Health Centre
24 Linhope St.
London, NW1 6HT
England
www.maharishi.co.uk

National Institute Of Ayurvedic Medicine
584 Milltown Road
Brewster, NY 10509
Ph. (845) 278-8700
Fax: (845) 278-8215
www.niam.com

Vinayak Ayurveda Center
2509 Virginia NE, Suite D
Albuquerque, NM 87110
Ph. (505)296-6522
Fax: (505)298-2932
www.ayur.com

Wise Earth School
P.O. Box 160
Candler, NC 28715
Ph. (828) 258-9999
www.wiseearth.com


CORRESPONDENCE COURSES

American Institute of Vedic Studies
P.O. Box 8357
Santa Fe, NM 87504-8357
Ph. (505) 983-9385
Fax: (505) 982-5807
www.vedanet.com

The American School of Ayurveda
460 Ridgedale Avenue
East Hanover, New Jersey 07936
Ph. (973) 887-8828
Fax: (973) 887-3088
www.lotusfair.com

The Ayurvedic Institute
11311 Menaul, NE
Albuquerque, NM 87112
Ph. (505)291-9698
Fax: (505)294-7572
www.ayurveda.com

Light Institute of Ayurvedic Teaching
P.O. Box 35284
Sarasota, FL 34242
Ph. (941)346-3518
Fax: (941)346-0800
www.ayurvedichealers.com

 

AYURVEDIC BEAUTY CARE

Auroma International
P.O. Box 1008
Dept. AH
Silver Lake, WI 53170
Ph. (262 )889-8569
Fax: (262) 889-8591
www.auroma.net

Bindi Facial Skin Care
A Division of Pratima Inc.
109-17 72nd Road
Lower Level
Forest Hills, NY 11375
Ph. (718) 268-7348
www.bindi.com

Internatural
33719 116th St./ Box AH
Twin Lakes, WI 53181
Ph. (800) 643-4221 (toll-free order line)
Fax: (262) 889-8591
www.internatural.com

Lotus Brands, Inc.
P.O. Box 1008/ Dept. AH
Silver Lake, WI 53170 USA
Ph. (262) 889-8561
Fax: (262) 889-8591
www.lotuspress.com

Maharishi Ayurveda Products
1068 Elkton Dr.
Colorado Springs, CO 80907
Ph. (800) 255-8332
www.mapi.com

Siddhi Ayurvedic Beauty Products
c/o Vinayak Ayurveda Center
2509 Virginia NE, Suite D
Albuquerque, NM 87110
Ph. (505) 296-6522
Fax: (505) 298-2932
www.ayur.com

 

A few more common alternative health myths I come across! (for Part I, click here)

Myth: I do not need to take any supplements, since I am eating good food.

Truth: I come across this very frequently in Pacific Northwest, regarding Vitamin D, and Vit B12 in Vegans.

Recent analysis of nutrient intakes of the U.S. population shows that a large percentage of people fall short of the average requirements of many nutrients. Almost everyone falls short of the average requirements for vitamin D and vitamin E, and more than one-third fall short of the average requirements for calcium, magnesium and vitamin A.

Resource:
Top 15 Foods Rich In Essential Minerals – https://www.healthambition.com/food-rich-minerals/

Myth: Since I am so healthy, I will be fine if I take herbs for my chest pain (…manage my fractures naturally, control a bad infection using natural herbals, not need gall bladder surgery etc….)

Truth: In a single word, NO!

Herbal and complementary medicine and techniques have a major role in preventive and chronic disease management, but in acute or emergency cases like chest pain (probably due to heart attack), severe abdominal pain (gall bladder infection/stone impaction, acute stomach ulcer or pancreatitis) accident, injury or fracture, you should still go to get urgent care from your medical provider rather than try to cure-it-yourself!

On the other hand, we have pushed the limits on prolonging life at all cost, not considering the quality of life as our time on this wonderful planet draws closer to its end.

Myth: I have to choose between either conventional or alternative medicine.

Truth: You can do both!

This is true even for cancer treatment. Integrative approaches research for symptom management in cancer patients and survivors have had promising results.

Cancer treatment centers with integrative health care programs may offer services such as acupuncture and meditation to help manage symptoms and side effects for patients who are receiving conventional cancer treatment. NCCIH-funded research has suggested that:

  1. Cancer patients who receive integrative therapies while in the hospital have less pain and anxiety.
  2. Massage therapy may lead to short-term improvements in pain and mood in patients with advanced cancer.
  3. Yoga may relieve the persistent fatigue that some women experience after breast cancer treatment.

Myth: Natural medicine has nothing in common with conventional medicine

Truth: Nature has been providing medicines to treat our diseases and relieve our suffering for many thousands of years.

Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. Many of our modern drugs were originally derived from either plant, animals, or fungi.

Examples are morphine from the opium poppy, aspirin from the white willow tree, anticoagulant coumadin from spoiled sweet clover. Periwinkle has yielded vinblastine (successful treatment of Hodgkin’s lymphoma, turning a disease that was once uniformly fatal into one that can now be totally cured in many patients) and vincristine (used for treating acute childhood leukemia).

Ethnobotany, the study of traditional human uses of plants, is recognized as an effective way to discover future medicines. In 2001, researchers identified 122 compounds used in modern medicine which were derived from “ethnomedical” plant sources; 80% of these have had an ethnomedical use identical or related to the current use of the active elements of the plant.

Myth: I can go for my surgery without discussing my herbs/vitamins/supplements with my doctor.

Truth: Certain supplements may increase the risk of bleeding, decrease your blood pressure or heart rate, affect the response to anesthesia, or adversely affect the outcome of your surgery….

It is very important to inform your doctor about the vitamins, herbals, OTC supplements etc you are taking. These might need to be stopped up to 2 weeks ahead of an elective surgery.

Here is a link for you to do a self-check on herbals.

Myth: Yoga can’t help serious diseases/it’s just for fun and flexibility

Truth: A Big YES!

There have been numerous studies proving the benefits of Yoga on several diseases, including cancers.

Myth: Alternative health websites just aren’t trustworthy.

Truth: There are fallible websites out there. But there are some good ones. You simply have to follow some rules so you can identify which are right.

If you’re visiting a health website for the first time, these five quick questions can help you decide whether the site is a helpful resource:

  1. Who? Who runs the Web site? Can you trust them?
    Be skeptical about anecdotal information from persons who have no formal training in nutrition or botanicals, or from personal testimonials (e.g. from store employees, friends, or online chat rooms and message boards) about incredible benefits or results obtained from using a product. Question these people on their training and knowledge in nutrition or medicine.
  2. What? What does the site say? Do the claims for the product seem exaggerated or unrealistic? Do its claims seem too good to be true? (Then probably they are not True!)
  3. When? When was the information posted or reviewed? Is it up to date?
  4. Where? Where did the information come from? Is it based on scientific research? Learn to distinguish hype from evidence-based science. Reputable websites will have real links at the bottom of websites, linking to scientific research. Check for university studies.
  5. Why? Why does the site exist? Is it selling something? Beware of such phrases such as: This is not a hoax or Send this to everyone you know.

Myth: Acupuncture, yoga, meditation, massage, all these have no scientific proof of action, so they must be woo-woo!

Truth: Many more insurance companies are approving the use of alternative therapies like yoga, acupuncture, massage therapy, chiropractic care, physical therapy etc. for acute or chronic pain, injuries, depression/anxiety and a variety of other mind-body conditions.

Meditation, yoga, and relaxation with imagery are recommended for routine use for common conditions, including anxiety and mood disorders. Stress management, yoga, massage, music therapy, energy conservation, and meditation are recommended for stress reduction, anxiety, depression, fatigue, and quality of life.

Preliminary studies of the effects of a single session of Swedish massage on hypothalamic-pituitary-adrenal and immune function in normal individuals.

Want to know how you can find truthful information?

To find reliable sources of scientifically sound information about vitamin/mineral supplements:

Look for scientific research findings on the dietary supplements. The National Center for Complementary and Integrative Health (NCCIH) and the National Institutes of Health (NIH) Office of Dietary Supplements (ODS), as well as other Federal agencies, have free publications, clearinghouses, and information on their Web sites.

The NIH Office of Dietary Supplements has a series of Vitamin and Mineral Fact Sheets that provide scientifically-based overviews of a number of vitamins and minerals. They can provide a good basis for a discussion with your doctor about whether or not you should take a vitamin/mineral supplement.

MedlinePlus is another good source of information on vitamins and minerals.

The Food and Drug Administration (FDA) has a variety of articles and consumer advisories to help consumers inform themselves about dietary supplements, including warnings and safety information, labeling, evaluation information, and FDA’s role in regulating dietary supplements.

For those interested in looking directly at scientific studies, the PubMed Dietary Supplement Subset is a good database to search: here, here, or here.

The Linus Pauling Institute’s Micronutrient Information Center is a source for scientifically accurate and peer-reviewed information regarding the roles of vitamins, minerals, phytochemicals (plant chemicals that may affect health), and other dietary factors, including some food and beverages, in preventing disease and promoting health. You can look here, here, and here. The subset is designed to limit search results to citations from a broad spectrum of dietary supplement literature including vitamin, mineral, phytochemical, ergogenic, botanical, and herbal supplements in human nutrition and animal models.

Some more helpful tips:
6 Things To Know When Selecting a Complementary Health Practitioner – https://nccih.nih.gov/health/tips/selecting
Steps in advising patients who are interested in complementary and alternative therapies – http://www.nature.com/nrclinonc/journal/v10/n11/fig_tab/nrclinonc.2013.125_F2.html
Talking about Complementary and Alternative Medicine with Health Care Providers: A Workbook and Tips – http://cam.cancer.gov/attachments/workbook/talking_about_cam_workbook.pdf

Sources:
http://www.crnusa.org/pdfs/CRNFactSheetNutrientShortfalls.pdf
Quantity is not necessarily better than Quality: What should medicine do when it can’t save your life?
http://www.newyorker.com/magazine/2010/08/02/letting-go-2
https://www.nlm.nih.gov/medlineplus/canceralternativetherapies.html
Heart rate variability and treatment outcome in major depression: a pilot study.
http://www.ncbi.nlm.nih.gov/pubmed/24769434
Insular cortex mediates increased pain tolerance in yoga practitioners.
http://www.ncbi.nlm.nih.gov/pubmed/23696275
Effect of Mindfulness-Based Stress Reduction on Anxiety, Depression and Stress in Women With Multiple Sclerosis.
http://www.ncbi.nlm.nih.gov/pubmed/26835467